So what is Shope, anyway? Shope is short for stereocircle, a four-sided figure used to take a picture of an object. The term was first used in 1801, by French Physician Emile Zolignon-GHolt, in reference to the lumps he found beneath the eyes in blind patients. Later, Shope came to mean “little head”. Some people might still use the term Shope, as in ‘a picture frame with a little head in it’, or ‘a frame with a little eye inside it’. However, as we’ll see shortly, Shope has a more exact scientific definition.
To clarify, we need to learn a little about how the body works when it comes to Shope. In its simplest form, shope is a measure of the rate of motion of an object that is coated with an extravasated antibody. The antibody, usually a DNA or polymer molecule, bonds with an enzyme on the outer surface of a smooth, flat object. This bond then allows the enzyme to push the object’s motion along the surface, as described by a simple mathematical model called Shrink’s Law. The number of extravasations determines the rate of motion.
The question then becomes, how can we use shope to study the health of human skin and hair? To answer this question, one would need to know something about the extravasated antibodies and their structures. Some shampoos contain an extravasated protein which, unlike normal proteins, has a double-helix structure. This structure, which is called a tetracyclic complex, allows scientists to examine the surface of domestic rabbit papillomas with the appropriate shope glass.
Shrink’s Law is useful in determining the rate of protein fusions at the level of each pore. If, for instance, there are two identical pore areas in a follicle (two different types of hair that grow from the same follicle), the rate of fusion will be identical. If, however, the hair types are different, then the rate of fusion will differ (i.e. between smooth and bumpy hairs). This law is particularly useful when it comes to tracking the path of a domestic rabbit papilloma virus.
Since the shope glass can detect the difference in fusion rates, it can also be used as a positive control. If the rate of fusion is different between two different sites on the same follicle, it shows that the domestic rabbit papillomas are infected by different viruses. By isolating these infections, the researchers can develop drugs that can target the virus responsible.
It is clear that the shope glass can play an important role in the diagnosis of domestic rabbit papilloma virus infections. However, like all medical instruments, it is not foolproof. It cannot identify if the virus causing the infection is human papilloma virus or a variant of the virus. The only way to be completely sure is by performing a DNA test. To date, only one DNA test – called a PCR – is reliable enough to confidently identify human papilloma virus in domestic rabbit papillomas.